Diabetes mellitus is the physical ailment that sets in once the body starts building up a resistance to the insulin generated by the pancreas. This results in the sugars flooding the bloodstream as they cannot be absorbed into the tissues of the body. Diabetes is also accompanied by excessive thirst and micturition, in most cases. This results in the depletion of the body's reserves of essential nutrients and minerals.
Diabetes mellitus is also a chronic disease caused by inherited and/or by the ineffectiveness of the insulin produced. Such a deficiency results in increased concentrations of glucose in the blood, which in turn damage many of the body's systems, in particular the blood vessels and nerves.
Vitamins and minerals play an important role in glucose metabolism, so these nutrients deficiencies and the potential utility of supplementation is relevant to the prevention and/or management of type 2 diabetes mellitus (DM).
Vitamins and minerals play diverse roles in our bodies. Initially, the nutrition community focused on the roles micronutrients play in preventing deficiency diseases such as scurvy, pellagra, and rickets. These supplements can regulate metabolism and gene expression and influence the development and progression of many chronic diseases. Eventually, we may be able to tailor nutritional recommendations to individuals' unique genetic makeup, thus increasing the potential benefit and positive outcomes of medical nutrition therapy.
Supplements – vitamins and minerals that our bodies require in small quantities for specific functions. They most commonly function as essential coenzymes and cofactors for metabolic reactions and thus help support basic cellular reactions (i.e., glycolysis, the citric acid cycle, lipid and amino acid metabolism) required to maintain energy production and life. Even moderate deficiencies can lead to serious disease states. These have been investigated as potential preventive and treatment agents for both type 1 and type 2 diabetes and for common complications of diabetes.
This supplement contains antioxidants, i.e. substances that neutralize or inactivate free radicals. Free radicals are trouble-makers. They are unstable oxygen molecules that damage cells, which in turn can lead to diseases like cancer, heart disease and nerve disease. These free radicals are formed by pollution, ultraviolet light, X rays, and even one's own body metabolism. By neutralizing free radicals, it is believed that we can prevent some of the damage caused by these harmful molecules.
Indications:
For diabetic patients with known nutritional deficit or at risk of developing nutritional deficiency and also indicated as dietary supplement during pregnancy and lactation:
- Effective in numerous neurodegenerative disorders
- Improves nerve conduction velocity
- Beneficial effects in diabetic neuropathy
- Helps in Alzheimer's disease and cognitive improvement
- Useful as anti stress strategy
- Improves nerve function
- Beneficial for a typical depression
About Composition:
Several vitamins and supplements have been shown to play some positive role in helping Diabetic Peripheral Neuropathy (DPN). These nutrients and supplements that have shown some supportive role toward:
Healthy blood sugar levels - the foundation of nerve health.
- Healthy nerves to alleviate direct nerve damage and its symptoms
- Healthy blood circulation to the nerves to indirectly support relief of diabetic neuropathy
Nicotinamide:
Niacin (vitamin B3 ) occurs in two forms: nicotinic acid and nicotinamide. The active coenzyme forms(nicotinamide adenine dinucleotide [NAD] and NAD phosphate) are essential for the function of hundreds of enzymes and normal carbohydrate, lipid, and protein metabolism. As a vitamin, the two compounds function similarly, but in pharmacological doses they have distinct effects. Nicotinic acid (1–3 g/day) is an effective treatment for dyslipidemia, although its use in people with diabetes has been limited because of its negative effect on glycemic control. Pharmacological doses of nicotinamide are being studied for their potential benefit in the prevention and treatment of diabetes. Animal studies suggest that nicotinamide acts by protecting pancreatic β-cells from autoimmune destruction by maintaining intracellular NAD levels and inhibiting the enzyme poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. Excessive PARP induction results in depletion of cytoplasmic NAD levels, induction of immunoregulatory genes, and cellular apoptosis (programmed cell death). Nicotinamide may additionally act as a weak antioxidant of nitric oxide radicals.
Zinc (As Zinc Sulphate):
The presence of a zinc deficiency in the body has also been suggested to contribute to the development of diabetes in some humans. Zinc itself may be a crucial element in insulin metabolism. Zinc is well-known as a powerful guardian against viral infections, and may also act to protect beta cells from destruction. Type 1 diabetics are often zinc deficient, and supplements have been shown to lower blood sugar levels in some type 1 cases. Zinc is vital among the minerals for diabetes control as it ensures that insulin is aptly released into the bloodstream. Diabetic persons should include zinc in their diet.
Pyridoxine HCl:
Pyridoxine supplements may be able to improve glucose tolerance, particularly for sufferers from gestational diabetes, or impaired glucose tolerance. Neuropathy, the severe damage caused to the nervous system by high blood sugar levels, may be associated with deficiency of pyridoxine. This supplement acts as an essential cofactor for hundreds of enzymes and plays a role in glucose, lipid, and amino acid metabolism and neurotransmitter synthesis. The active coenzyme form of the vitamin, pyridoxal-5-phosphate, in muscle tissue is closely associated with glycogen phosphorylase. Vitamin B6 also has a strong role to play in the prevention of diabetes-related complications.
Folic Acid:
Folic acid is the synthetic form of the vitamin. Folate, yet another B vitamin (B9), is also essential to many of body's functions. Folate is an essential coenzyme for reactions involving the transfer of one-carbon-units in amino acid and nucleic acid synthesis. The human body needs folate to make, repair, and regulate DNA, to develop red blood cells, to support good nervous system function, and to act as a cofactor in many of the biological reactions that keep you healthy. Folate participates in the breakdown of fat in fat cells and may have some role in the prevention of obesity and type-2 diabetes. Many people know that diabetes is a disease of blood sugar control, but many do not know that it is also a disease of fat storage. Any dietary nutrient that plays a supportive role in proper fat metabolism needs to be a regular part of the diabetes and pre-diabetes diet. Once eaten folate must chemically change to become the activated, functional L-methylfolate. The better supplements for DPN contain L-methylfolate so the active form of folate is being directly delivered to your system without having to go through the conversion process.
Selenium (As Sodium Selenite):
Selenium, a trace mineral and antioxidant which plays a crucial role in human health, is a basic component of selenoprotein, an important enzyme in the body. Selenoproteins play a functional role in redox homeostasis, thyroid hormone metabolism, and protection from oxidative stress and inflammation. Oxidative stress reduces insulin secretion and increases insulin resistance in some experimental models and may thus play a causal role in the pathogenesis of diabetes. Selenium, an essential trace element, is involved in the complex system of defense against oxidative stress through selenium-dependent glutathione peroxidases and other selenoproteins.
Because of its antioxidant properties, selenium might thus prevent the development of diabetes and has been reported to have strong antidiabetic and insulin-mimetic effects.
Chromium (Chromium Picolinate):
Chromium is an essential trace mineral that plays a role in the metabolism of glucose and in supporting healthy blood sugar levels in people with diabetes. It benefits nerve health in diabetes and pre-diabetes through this well-known ability to support healthy blood sugar levels. Chromium positively supports healthy blood sugar levels and support insulin sensitivity, and healthy blood sugar levels in some diabetics. Optimal levels may reduce insulin resistance, improve blood sugar control, and may help to reduce the risk of cardiovascular disease and type-2 diabetes. Supplementation may also help to reduce triglycerides and total cholesterol while improving HDL " good"" cholesterol.
Chromium appears to act by enhancing or potentiating insulin's actions. No chromium-containing enzyme has been discovered, and the biologically active form of chromium is still uncertain. Chromium's actions have been attributed to an increase in the number of insulin receptors, increased binding of insulin to the insulin receptor, and increased activation of the insulin receptor in the presence of insulin. In vitro studies using organic forms of chromium have documented altered activity of phosphotyrosine phosphatase and phosphotyrosine kinase.
Cyanocobalamin:
Vitamin B 12 may have a strong role to play when treating diabetic neuropathy. The presence of vitamin B 12 is necessary for the correct functioning of nerve cells and therefore taking it as a supplement may help to reduce nerve damage. Vitamin B 12's main functions are in the formation of red blood cells and DNA that make up your genes. It is involved in having a healthy nervous system, and plays a vital role in the metabolism of healthy fats essential for maintenance of the important covering that surrounds your nerves known as the myelin sheath. In the diabetic, B12 is typically used to assist in the management of diabetic neuropathy, and for general nerve health. The main property of vitamin B 12 that has been studied for DPN is its role in managing homocysteine levels - Elevated levels of homocysteine in the blood have been associated with poor circulation, and it is believed that the decreased circulation in the tiny blood vessels that feed the nerves are part of the problem in people with DPN.
Side Effects:
The product is POSSIBLY SAFE for most adults when taken by mouth. There is no disadvantage associated with the product if taken under the recommended usage.
Contraindications:
Hypersensitivity to any ingredient of the composition.
Special Precautions & Warnings:
For Pregnancy and Breast-Feeding:
Pregnant and lactating mothers should not take any single supplement in higher-than- normal doses unless recommended by a health-care provider for a special condition. The combination should only be used in pregnancy and lactation if benefits outweigh the risks.
Stay on the safe side and avoid use.
Storage:
Store in a cool, dry and dark place.